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• St. Joseph was founded in 1826 by French trapper Joseph Robidoux, who named the community after his patron saint.
• With 4,600 jobs in animal pharmaceuticals, agriculture chemicals, food processing, health care, animal research and development and seed production, St. Joseph has emerged as a national center of animal and life sciences.

• St. Joseph is where the Pony Express began its life and Jesse James ended his. Curiously, the two events happened on the same date, April 3, 22 years apart.

• Dr. Dan L. Colgan, St. Joseph superintendent of schools, was named 2002 "Missouri Superintendent of the Year" by the Missouri Association of School Administrators.
• Lewis and Clark camped twice in what was later St. Joseph, then known as St. Michael’s Prairie.
• In 1887, St. Joseph became the second city in the U.S.—Richmond, Virginia, was the first—to have electric streetcars.
• The St. Joseph Stockyards opened in that same year, and the city was soon second only to Chicago as a meat packing center.
• The largest employer in St. Joseph is Heartland Health, which operates Heartland Health Regional Medical Center, recently ranked in the top 100 hospitals for heart and orthopedic specialties. economic impact of $139 million on the local community.
• Founded in only 1965, Missouri Western State College has grown rapidly to more than 5,200 students and a full- time staff of 550. Missouri Western has a direct annual economic impact of $139 million on the local community.
• St. Joseph Parkway runs 26 miles through the heart of the city. Built in 1918, it’s listed on the National Register of Historic Places.
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